1,531 research outputs found
A Systematic Approach to Constructing Incremental Topology Control Algorithms Using Graph Transformation
Communication networks form the backbone of our society. Topology control
algorithms optimize the topology of such communication networks. Due to the
importance of communication networks, a topology control algorithm should
guarantee certain required consistency properties (e.g., connectivity of the
topology), while achieving desired optimization properties (e.g., a bounded
number of neighbors). Real-world topologies are dynamic (e.g., because nodes
join, leave, or move within the network), which requires topology control
algorithms to operate in an incremental way, i.e., based on the recently
introduced modifications of a topology. Visual programming and specification
languages are a proven means for specifying the structure as well as
consistency and optimization properties of topologies. In this paper, we
present a novel methodology, based on a visual graph transformation and graph
constraint language, for developing incremental topology control algorithms
that are guaranteed to fulfill a set of specified consistency and optimization
constraints. More specifically, we model the possible modifications of a
topology control algorithm and the environment using graph transformation
rules, and we describe consistency and optimization properties using graph
constraints. On this basis, we apply and extend a well-known constructive
approach to derive refined graph transformation rules that preserve these graph
constraints. We apply our methodology to re-engineer an established topology
control algorithm, kTC, and evaluate it in a network simulation study to show
the practical applicability of our approachComment: This document corresponds to the accepted manuscript of the
referenced journal articl
A Systematic Approach to Constructing Families of Incremental Topology Control Algorithms Using Graph Transformation
In the communication systems domain, constructing and maintaining network
topologies via topology control (TC) algorithms is an important cross-cutting
research area. Network topologies are usually modeled using attributed graphs
whose nodes and edges represent the network nodes and their interconnecting
links. A key requirement of TC algorithms is to fulfill certain consistency and
optimization properties to ensure a high quality of service. Still, few
attempts have been made to constructively integrate these properties into the
development process of TC algorithms. Furthermore, even though many TC
algorithms share substantial parts (such as structural patterns or tie-breaking
strategies), few works constructively leverage these commonalities and
differences of TC algorithms systematically. In previous work, we addressed the
constructive integration of consistency properties into the development
process. We outlined a constructive, model-driven methodology for designing
individual TC algorithms. Valid and high-quality topologies are characterized
using declarative graph constraints; TC algorithms are specified using
programmed graph transformation. We applied a well-known static analysis
technique to refine a given TC algorithm in a way that the resulting algorithm
preserves the specified graph constraints.
In this paper, we extend our constructive methodology by generalizing it to
support the specification of families of TC algorithms. To show the feasibility
of our approach, we reneging six existing TC algorithms and develop e-kTC, a
novel energy-efficient variant of the TC algorithm kTC. Finally, we evaluate a
subset of the specified TC algorithms using a new tool integration of the graph
transformation tool eMoflon and the Simonstrator network simulation framework.Comment: Corresponds to the accepted manuscrip
A cross-national study on gender differences in suicide intent
BACKGROUND: Suicide accounts for over 58,000 deaths in Europe per annum, where suicide attempts are estimated to be 20 times higher. Males have been found to have a disproportionately lower rate of suicide attempts and an excessively higher rate of suicides compared to females. The gender difference in suicide intent is postulated to contribute towards this gender imbalance. The aim of this study is to explore gender differences in suicide intent in a cross-national study of suicide attempts. The secondary aims are to investigate the gender differences in suicide attempt across age and country.
METHODS: Data on suicide attempts (acquired from the EU-funded OSPI-Europe project) was obtained from eight regions in Germany, Hungary, Ireland and Portugal. Suicide intent data was categorized into 'Non-habitual Deliberate Self-Harm' (DSH), 'Parasuicidal Pause' (SP), 'Parasuicidal Gesture' (SG), and 'Serious Suicide Attempt' (SSA), applying the Feuerlein scale. Gender differences in intent were explored for significance by using X2)-tests, odds ratios, and regression analyses.
RESULTS: Suicide intent data from 5212 participants was included in the analysis. A significant association between suicide intent and gender was found, where 'Serious Suicide Attempts' (SSA) were rated significantly more frequently in males than females (p < .001). There was a statistically significant gender difference in intent and age groups (p < .001) and between countries (p < .001). Furthermore, within the most utilised method, intentional drug overdose, 'Serious Suicide Attempt' (SSA) was rated significantly more often for males than females (p < .005).
CONCLUSIONS: Considering the differences in suicidal intent between males and females highlighted by the current study, gender targeted prevention and intervention strategies would be recommended
A Systematic Approach and Guidelines to Developing a Triple Graph Grammar
Engineering processes are often inherently concurrent, involving multiple stakeholders working in parallel, each with their own tools and artefacts. Ensuring and restoring the consistency of such artefacts is a crucial task, which can be appropriately addressed with a bidirectional transformation (bx ) language. Although there exist numerous bx languages, often with corresponding tool support, it is still a substantial challenge to learn how to actually use such bx languages. Triple Graph Grammars (TGGs) are a fairly established bx language for which multiple and actively developed tools exist. Learning how to master TGGs is, however, currently a frustrating undertaking: a typical paper on TGGs dutifully explains the basic "rules of the game" in a few lines, then goes on to present the latest groundbreaking and advanced results. There do exist tutorials and handbooks for TGG tools but these are mainly focussed on how to use a particular tool (screenshots, tool workflow), often presenting exemplary TGGs but certainly not how to derive them systematically. Based on 20 years of experience working with and, more importantly, explaining how to work with TGGs, we present in this paper a systematic approach and guidelines to developing a TGG from a clear, but unformalised understanding of a bx
Quality assurance process within the RAdiosurgery for VENtricular TAchycardia (RAVENTA) trial for the fusion of electroanatomical mapping and radiotherapy planning imaging data in cardiac radioablation
A novel quality assurance process for electroanatomical mapping (EAM)-to-radiotherapy planning imaging (RTPI) target transport was assessed within the multi-center multi-platform framework of the RAdiosurgery for VENtricular TAchycardia (RAVENTA) trial. A stand-alone software (CARDIO-RT) was developed to enable platform independent registration of EAM and RTPI of the left ventricle (LV), based on pre-generated radiotherapy contours (RTC). LV-RTC were automatically segmented into the American-Heart-Association 17-segment-model and a manual 3D-3D method based on EAM 3D-geometry data and a semi-automated 2D-3D method based on EAM screenshot projections were developed. The quality of substrate transfer was evaluated in five clinical cases and the structural analyses showed substantial differences between manual target transfer and target transport using CARDIO-RT
Search for Doubly-Charged Higgs Boson Production at HERA
A search for the single production of doubly-charged Higgs bosons H^{\pm \pm}
in ep collisions is presented. The signal is searched for via the Higgs decays
into a high mass pair of same charge leptons, one of them being an electron.
The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment
at HERA. No evidence for doubly-charged Higgs production is observed and mass
dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs
boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only
decays into an electron and a muon via a coupling of electromagnetic strength
h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the
H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged
Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3,
masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl
Response-adapted omission of radiotherapy and comparison of consolidation chemotherapy in intermediate- and advanced-stage children and adolescents with classic Hodgkin lymphoma: a titration study with an embedded non-inferiority randomised controlled trial
BACKGROUND: Children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma achieve an event-free survival at 5 years of about 90% after treatment with vincristine, etoposide, prednisone, and doxorubicin (OEPA) followed by cyclophosphamide, vincristine, prednisone, and procarbazine (COPP) and radiotherapy, but long-term treatment effects affect survival and quality of life. We aimed to investigate whether radiotherapy can be omitted in patients with morphological and metabolic adequate response to OEPA and whether modified consolidation chemotherapy reduces gonadotoxicity. METHODS: Our study was designed as a titration study with an open-label, embedded, multinational, non-inferiority, randomised controlled trial, and was carried out at 186 hospital sites across 16 European countries. Children and adolescents with newly diagnosed intermediate-stage (treatment group 2) and advanced-stage (treatment group 3) classical Hodgkin lymphoma who were younger than 18 years and stratified according to risk using Ann Arbor disease stages IIAE, IIB, IIBE, IIIA, IIIAE, IIIB, IIIBE, and all stages IV (A, B, AE, and BE) were included in the study. Patients with early disease (treatment group 1) were excluded from this analysis. All patients were treated with two cycles of OEPA (1¡5 mg/m(2) vincristine taken intravenously capped at 2 mg, on days 1, 8, and 15; 125 mg/m(2) etoposide taken intravenously on days 1â5; 60 mg/m(2) prednisone taken orally on days 1â15; and 40 mg/m(2) doxorubicin taken intravenously on days 1 and 15). Patients were randomly assigned to two (treatment group 2) or four (treatment group 3) cycles of COPP (500 mg/m(2) cyclophosphamide taken intravenously on days 1 and 8; 1¡5 mg/m(2) vincristine taken intravenously capped at 2 mg, on days 1 and 8; 40 mg/m(2) prednisone taken orally on days 1 to 15; and 100 mg/m(2) procarbazine taken orally on days 1 to 15) or COPDAC, which was identical to COPP except that 250 mg/m(2) dacarbazine administered intravenously on days 1 to 3 replaced procarbazine. The method of randomisation (1:1) was minimisation with stochastic component and was centrally stratified by treatment group, country, trial sites, and sex. The primary endpoint was event-free survival, defined as time from treatment start until the first of the following events: death from any cause, progression or relapse of classical Hodgkin lymphoma, or occurrence of secondary malignancy. The primary objectives were maintaining 90% event-free survival at 5 years in patients with adequate response to OEPA treated without radiotherapy and to exclude a decrease of 8% in event-free survival at 5 years in the embedded COPDAC versus COPP randomisation to show non-inferiority of COPDAC. Efficacy analyses are reported per protocol and safety in the intention-to-treat population. The trial is registered with ClinicalTrials.gov (trial number NCT00433459) and EUDRACT (trial number 2006-000995-33), and is closed to recruitment. FINDINGS: Between Jan 31, 2007, and Jan 30, 2013, 2102 patients were recruited. 737 (35%) of the 2102 recruited patients were in treatment group 1 (early-stage disease) and were not included in our analysis. 1365 (65%) of the 2102 patients were in treatment group 2 (intermediate-stage disease; n=455) and treatment group 3 (advanced-stage disease; n=910). Of these 1365, 1287 (94%) patients (435 [34%] of 1287 in treatment group 2 and 852 [66%] of 1287 in treatment group 3) were included in the titration trial per-protocol analysis. 937 (69%) of 1365 patients were randomly assigned to COPP (n=471) or COPDAC (n=466) in the embedded trial. Median follow-up was 66¡5 months (IQR 62¡7â71¡7). Of 1287 patients in the per-protocol group, 514 (40%) had an adequate response to treatment and were not treated with radiotherapy (215 [49%] of 435 in treatment group 2 and 299 [35%] of 852 in treatment group 3). 773 (60%) of 1287 patients with inadequate response were scheduled for radiotherapy (220 [51%] of 435 in the treatment group 2 and 553 [65%] of 852 in treatment group 3. In patients who responded adequately, event-free survival rates at 5 years were 90¡1% (95% CI 87¡5â92¡7). event-free survival rates at 5 years in 892 patients who were randomly assigned to treatment and analysed per protocol were 89¡9% (95% CI 87¡1â92¡8) for COPP (n=444) versus 86¡1% (82¡9â89¡4) for COPDAC (n=448). The COPDAC minus COPP difference in event-free survival at 5 years was â3¡7% (â8¡0 to 0¡6). The most common grade 3â4 adverse events (intention-to-treat population) were decreased haemoglobin (205 [15%] of 1365 patients during OEPA vs 37 [7%] of 528 treated with COPP vs 20 [2%] of 819 treated with COPDAC), decreased white blood cells (815 [60%] vs 231 [44%] vs 84 [10%]), and decreased neutrophils (1160 [85%] vs 223 [42%] vs 174 [21%]). One patient in treatment group 2 died of sepsis after the first cycle of OEPA; no other treatment-related deaths occurred. INTERPRETATION: Our results show that radiotherapy can be omitted in patients who adequately respond to treatment, when consolidated with COPP or COPDAC. COPDAC might be less effective, but is substantially less gonadotoxic than COPP. A high proportion of patients could therefore be spared radiotherapy, eventually reducing the late effects of treatment. With more refined criteria for response assessment, the number of patients who receive radiotherapy will be further decreased. FUNDING: Deutsche Krebshilfe, Elternverein fĂźr Krebs-und leukämiekranke Kinder GieĂen, Kinderkrebsstiftung Mainz, Tour der Hoffnung, Menschen fĂźr Kinder, Programme Hospitalier de Recherche Clinique, and Cancer Research UK
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
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